Relationship between cervical vertebral maturation and dental development in a sample of yemeni children and adolescents / Relación entre la maduración vertebral cervical y el desarrollo dental en una muestra de niños y adolescentes yemeníes

Objective: This study was conducted to investigate the relationship between dental development and cervical vertebral maturation stages in a group of Yemeni children and adolescents. Materials an Methods: The study included digital panoramic radiographs and lateral skull cephalograms obtained from 207 Yemeni subjects­122 females and 85 males aged between 8 to 18 years. Dental maturity was evaluated according to the method of Demirijian et al., calcification stages of the left mandibular canines, first and second premolars and second molars were assessed. Skeletal maturity was assessed by the cervical vertebral maturation (CVM) stages according to the method of Baccetti et al. Correlation between CVM and dental maturation was evaluated by Spearman rank-order correlation coefficient (SROCC). Results: CVM and dental calcification stages were highly correlated (p<0.001) in both genders, ranging from 0.686 to 0.873 for females and 0.787 to 0.871 for males. Calcification stages of the second molars showed the strongest correlation with CVM. Conclusion: Calcification stages of the second molar may be used as a reliable maturation indicator. Dental maturation may be applied to determine the skeletal maturity status of Yemeni children and adolescents.

Objetivo: Este estudio se realizó para investigar la relación entre el desarrollo dental y las etapas de maduración vertebral cervical en un grupo de niños y adolescentes yemeníes. Material y Métodos: El estudio incluyó radiografías panorámicas digitales y cefalogramas laterales del cráneo obtenidos de 207 sujetos yemeníes: 122 mujeres y 85 hombres de entre 8 y 18 años. La madurez dental se evaluó de acuerdo con el método de Demirijian et al. Se evaluaron las etapas de calcificación de los caninos mandibulares izquierdos, primer y segundo premolares y segundos molares. La madurez esquelética se evaluó mediante las etapas de maduración vertebral cervical (CVM) de acuerdo con el método de Baccetti et al. La correlación entre la CVM y la maduración dental se evaluó mediante el coeficiente de correlación de orden de rango de Spearman (SROCC). Resultado: Las etapas de CVM y calcificación dental estuvieron altamente correlacionadas (p<0.001) en ambos sexos, con un rango de 0.686 a 0.873 para las mujeres y 0.787 a 0.871 para los hombres. Las etapas de calcificación de los segundos molares mostraron la correlación más fuerte con CVM. Conclusión: las etapas de calcificación del segundo molar pueden usarse como un indicador de maduración confiable. La maduración dental puede aplicarse para determinar el estado de madurez esquelética de los niños y adolescentes yemeníes.

The Reliability of Fishman and Nolla Methods in Prediction of Chronological Age of Yemeni Children / A confiabilidade dos métodos Fishman e Nolla na predição da idade cronológica de crianças iemenitas

Objective: This cross-sectional school based study aimed to assess the reliability of Fishman and Nolla methods in predicting the chronological age for Yemeni children. Material and Methods: Orthopantomographs and left handwrist radiographs were taken for 358 Yemeni children (193 boys and 165 girls) 8 - 16 years. Skeletal age estimated by Fishman method and dental age estimated by Nolla method were compared to chronological age using SPSS version 21, statistical significance was predetermined at P < 0.05 , using Intraclass Correlation CoefficientICC and Wilcoxon signed rank test. Results: The mean chronological, skeletal and dental ages were 12.00 ± 2.25 years, 12.39 ± 1.65 years and 11.32 ± 2.65 years, respectively. Intraclass correlation coefficient showed strong correlation between chronological age and skeletal and dental ages. Wilcoxon test showed Fishman method significantly underestimated the chronological age by 0.44 ± 1.26 years in boys and non-significantly underestimated the chronological age by 0.02 ± 1.08 years in girls. Nolla method significantly underestimated the chronological age by 0.59 ± 1.28 years in boys and 0.78 ± 1.21 years in girls. Conclusions: Chronological age of Yemeni children is highly correlated to skeletal age estimated by Fishman method and dental age estimated by Nolla method. However, the two methods underestimate the chronological age of Yemeni children.(AU)

Objetivo: Este estudo transversal de base escolar teve como objetivo avaliar a confiabilidade dos métodos Fishman e Nolla na predição da idade cronológica em crianças iemenitas. Material e Métodos: Foram realizadas ortopantomografias e radiografias do punho esquerdo em 358 crianças iemenitas (193 meninos e 165 meninas) de 8 a 16 anos. A idade esquelética estimada pelo método Fishman e a idade odontológica estimada pelo método Nolla foram comparadas com a idade cronológica pelo, utilizando-se o programa SPSS versão 21; a significância estatística foi predeterminada em P < 0,05, pelo coeficiente de correlação intraclasseICC e pelo teste de Wilcoxon. Resultados: As idades cronológica, esquelética e odontológica média foram de 12,00 ± 2,25 anos, 12,39 ± 1,65 anos e 11,32 ± 2,65 anos, respectivamente. O coeficiente de correlação intraclasse mostrou forte correlação entre idade cronológica e idade esquelética e dentária. O teste de Wilcoxon mostrou que o método Fishman subestimou significativamente a idade cronológica em 0,44 ± 1,26 anos nos meninos e não subestimou significativamente a idade cronológica em 0,02 ± 1,08 anos nas meninas. O método Nolla subestimou significativamente a idade cronológica em 0,59 ± 1,28 anos nos meninos e 0,78 ± 1,21 anos nas meninas. Conclusões: A idade cronológica de crianças iemenitas está altamente correlacionada à idade esquelética estimada pelo método Fishman e à idade dentária estimada pelo método Nolla. No entanto, os dois métodos subestimam a idade cronológica das crianças iemenitas.(AU)

Association of Khat chewing, smoking, age and sex with periodontal status among Yemeni adults / Associação da mastigação de Khat, tabagismo, idade e gênero com a condição periodontal entre adultos iemenitas

Objective: Periodontal diseases are very common dental disease. Many risk factors may play significant role in the periodontal disease initiation and progression. This study was performed to evaluate the effects of khat chewing, smoking, age and gender on periodontal status among Yemeni adults. Material and Methods: This cross-sectional study was performed on 1231 patients attending the outpatient dental polyclinics of University of Science and Technology during the academic years 2017/2018. All completed sheets were collected throughout the year by the supervisors. Data cleaning, descriptive statistics, and inferential statistics were then performed. Results: Khat chewers were more frequent than non-chewers counterparts (60.7% vs. 39.3%). The prevalence of smoking was 25.5% (297 patients). Study results indicated that periodontitis is more associated with female gender and participants aged more than 35 years old. Results also showed that female and age older participants aged more than 35 years were significantly associated with gingival recession. Mean number of the teeth with gingival recession in male patients were higher than in females. Male gender and patients aged more than 35 years old were significantly associated with furcation involvement. Conclusion: The present study has shown females gender and age older than 35 seem to be risk factors of periodontal diseases. Males has more teeth affected by gingival recession and more furcation involvement (AU)

Objetivo: As doenças periodontais são patologias dentárias com alta prevalência. Diversos fatores de risco podem desempenhar papel significativo no início e progressão das doenças periodontais. Este estudo foi realizado para avaliar os efeitos da mastigação de khat, tabagismo, idade e gênero na condição periodontal de adultos iemenitas. Material e Métodos: Este estudo transversal foi realizado em 1231 pacientes atendidos nas policlínicas odontológicas ambulatoriais da Universidade de Ciência e Tecnologia durante os anos acadêmicos de 2017/2018 através de um questionário para coleta de dados préestabelecido. Todas os questionários preenchidos foram coletados ao longo do ano pelos supervisores. A apuração dos dados, estatística descritiva e estatística inferencial foram realizadas. Resultados: os mastigadores de Khat foram mais frequentes do que as não-mastigadores (60,7% vs. 39,3%). A prevalência de tabagismo foi de 25,5% (297 pacientes). Os resultados do estudo indicaram que a periodontite está mais associada ao gênero feminino e aos participantes com mais de 35 anos de idade. Os resultados também mostraram que participantes do gênero feminino e acima de 35 anos foram significativamente associadas à recessão gengival. O número médio de dentes com recessão gengival em pacientes do gênero masculino foi maior que no feminino. O gênero masculino e os pacientes com mais de 35 anos de idade foram significativamente associados ao envolvimento da furca. Conclusão: O presente estudo mostrou que o gênero feminino e a idade acima de 35 anos parecem ser fatores de risco para doenças periodontais. Pacientes do gênero masculino têm mais dentes afetados pela recessão gengival e mais envolvimento de furca.(AU)

The prevalence of tooth wear among a group of yemeni adults / La prevalencia del desgaste dental entre un grupo de adultos yemeníes

This study aimed at investigating tooth wear prevalence and determining the associated factors among a group of Yemeni adults. It is a preliminary cross-sectional and analytical investigation conducted on 600 participants aged 20­50 years. The participants were purposively selected from two main cities (Sana'a and Aden) with an equal sample size and divided equally by gender. For administering a questionnaire, interviews were conducted with all participants before clinically examining them. Using the Tooth Wear Index (TWI), tooth wear was assessed. Data were analyzed using the chi-square test to identify the relationship between tooth wear and associated factors., Tooth wear was prevalent among 78.67% of the participants; of which 64.83% were in anterior teeth, 63.83% in posterior teeth, 74% in maxillary teeth, and approximately 74.5% in mandibular teeth. It also was 100% prevalent in the 31-40 and 41-50 age groups, while it was 67.2% in the 20-30 age group. This showed that tooth wear prevalence was significantly higher in the two oldest groups than in the youngest group (p<0.001). Moreover, khat chewing, location, highly frequent consumption of foods and high frequency of acidic drinks consumption were critical indicators of tooth wear. Besides, a low education level, smoking and a low socio-economic status were associated with tooth wear. Finally, the study revealed that tooth wear is highly prevalent among adults in two Yemeni cities, and socio-behavioral risk indicators such as khat chewing and cigarette smoking have a significantly association with tooth wear.

Este estudio tuvo como objetivo investigar la prevalencia del desgaste dental y determinar los factores asociados en un grupo de adultos yemeníes. Es una investigación preliminar analítica y transversal que se lleva a cabo en 600 participantes de entre 20 y 50 años. Los participantes fueron seleccionados a propósito de dos ciudades principales (Sana'a y Aden) con un tamaño de muestra igual y divididos por igual por género. Para administrar un cuestionario, se realizaron entrevistas con todos los participantes antes de examinarlos clínicamente. Usando el Índice de Desgaste Dental, se evaluó el desgaste dental. Los datos se analizaron utilizando la prueba de chi-cuadrado para identificar la relación entre el desgaste dental y los factores asociados. El degaste dental tuvo una prevalencia del 78,67% de los participantes; de los cuales 64.83% en dientes anteriores, 63.83% en dientes posteriores, 74% en dientes maxilares y aproximadamente 74.5% en dientes mandibulares. Fue 100% prevalente en los grupos de edad 31-40 y 41-50, mientras que la prevalencia fue 67.2% en el grupo de edad 20-30. Esto demostró que la prevalencia del desgaste dental fue significativamente mayor en los dos grupos de personas mayores que en el grupo más joven (p<0.001). Además, mascar khat, la ubicación, el consumo muy frecuente de alimentos y la alta frecuencia de bebidas ácidas fueron indicadores críticos del desgaste dental. Además, el bajo nivel educativo, el tabaquismo y el bajo nivel socioeconómico se asociaron con el degaste dental. Finalmente, el estudio reveló que el desgaste dental es altamente prevalente entre los adultos en dos ciudades yemeníes, y los indicadores de riesgo socioconductual como la masticación de khat y el tabaquismo tienen una asociación significativa con el desgaste dental.

Prevalence of carotid artery calcification detected by digital panoramic radiographs in a sample of yemeni dental patients / Prevalencia de la calcificación de la arteria carótida detectada por radiografías panorámicas digitales en una muestra de pacientes dentales yemeníes

Background: Carotid artery calcification (CAC) is one of risk factors of cardiovascular disorders (CVDs). Digital panoramic radiographs can detect it. Aim of the study: This study aimed to determine the prevalence of CAC detected by digital panoramic radiographs in a sample of Yemeni dental patients. Materials and Methods: An observational and analytical cross-sectional study was used to investigate a convenience sample of 443 patients. These patients were interviewed face-to-face for their socio-demographic information and their medical background regarding CVDs and associated risk factors. The researchers for detection of CAC assessed the digital panoramic radiographs. Results: High income and middle-aged patients were risk factors of CVDs significantly associated with increased incidence of CAC (42 patients (9.5%) and 32 patients (7.2%), respectively). Patients with a previous medical consultation, previous medications and family history of CVDs revealed a significant higher prevalence of CAC (p=0.001). Conclusion: There was an increased prevalence of CAC detected on digital panoramic radiographs, as a risk factor of CVDs. CAC was more common in females than males.

Antecedentes: La calcificación de la arteria carótida (CAC) es uno de los factores de riesgo de enfermedades cardiovasculares (ECV). La CAC puede ser detectada por radiografías panorámicas digitales. Objetivo del estudio: Este estudio tuvo como objetivo determinar la prevalencia de CAC detectada por radiografías panorámicas digitales en una muestra de pacientes dentales yemeníes. Materiales y métodos: Se utilizó un estudio transversal observacional y analítico para investigar una muestra de conveniencia de 443 pacientes. Estos pacientes fueron entrevistados en persona para obtener su información sociodemográfica y sus antecedentes médicos con respecto a las ECV y los factores de riesgo asociados. Los investigadores evaluaron las radiografías panorámicas digitales para detectar CAC. Resultados: Los pacientes de ingresos altos y de mediana edad fueron factores de riesgo de ECV significativamente asociados con una mayor incidencia de CAC (42 pacientes (9,5%) y 32 pacientes (7,2%), respectivamente). Los pacientes con una consulta médica previa, medicamentos previos y antecedentes familiares de ECV revelaron una prevalencia significativamente mayor de CAC (p=0.001). Conclusión: Hubo una mayor prevalencia de CAC detectada en radiografías panorámicas digitales como factor de riesgo de ECV, y CAC fue más común en mujeres que en hombres.

Prevalence of impacted teeth among a sample of yemeni population and their association with sex and age / Prevalencia de dientes impactados entre una muestra de población yemení y su asociación con el sexo y la edad

Aim: the aim of the study was to assess the prevalence of impacted teeth and its association with sex and age among a sample of the Yemeni population. Materials and Methods: A cross sectional study design was employed. The study included 999 radiographical records of patients who had panoramic X- rays previously done. All radiographs were assessed for the number and type of impacted teeth, pathology-associated impaction, sex, age and location (mandible and/or maxilla). The collected data was analyzed using SPSS®version21 software. Results: The study sample comprised digital panoramic radiographs of Yemeni patients aged 17 to 54 years (mean 26.6 years). The present study found 542 patients (54.3%) presented with at least one impacted tooth. The 17 to 25 years age group of the study sample had the highest prevalence of tooth impaction (28.6%). Only 10 (1.0%) case presented pathologies associated with the impacted teeth. There was a significant difference in the number of male 203 (20.3%) and female 339 (33.9%) patients with impacted teeth (p=0.031). Impacted teeth occurred slightly more often in the mandible (42.8%) compared to the maxilla (42.4%). Conclusion: The prevalence of impacted teeth among a sample of Yemeni population was high. Third molars and canines were the most common impacted teeth. The prevalence of impacted teeth in females was higher than in males and it was higher in the mandible than in the maxilla, with the younger patients with a higher prevalence of impaction.

Objetivo: el objetivo del estudio fue evaluar la prevalencia de dientes impactados y su asociación con el sexo y la edad en una muestra de la población yemení. Material y Métodos: se empleó un diseño de estudio transversal. El estudio incluyó 999 registros radiográficos de pacientes con radiografías panorámicas realizadas previamente. Todas las radiografías fueron evaluadas en relación al número y tipo de dientes impactados, patología asociada a la impactación, sexo, edad y ubicación (mandíbula y/o maxilar). Los datos recopilados se analizaron utilizando el software SPSS® version 21. Resultados: La muestra del estudio comprendió radiografías panorámicas digitales de pacientes yemeníes entre 17 a 54 años (media 26,6 años). El presente estudio encontró que 542 pacientes (54,3%) presentaron al menos un diente impactado. El grupo de edad de 17 a 25 años de la muestra de estudio tuvo la mayor prevalencia de impactación dental (28,6%). Solo 10 casos (1,0%) presentaron patologías asociadas a los dientes impactados. Hubo una diferencia significativa en el número de pacientes masculinos 203 (20.3%) y femeninos 339 (33.9%) con dientes impactados (p=0.031). Los dientes impactados ocurrieron con un poco más de frecuencia en la mandíbula (42.8%) en comparación con el maxilar (42.4%). Conclusión: La prevalencia de dientes impactados entre una muestra de población yemení fue alta. Los terceros molares y caninos fueron los dientes más comúnmente impactados. La prevalencia de dientes impactados en las mujeres fue mayor que en los hombres y fue mayor en la mandíbula que en el maxilar, y los pacientes más jóvenes mostraron una mayor prevalencia de impactación.

Perception and confidence levels among dental students and interns in performing various endodontic procedures / Niveles de percepción y confianza entre estudiantes de odontología y pasantes en la realización de diversos procedimientos de endodoncia

Aim: The present study aimed to collect information from senior students and new interns enrolled at the College of Dentistry, University of Science and Technology (UST), regarding their confidence levels in performing endodontic treatments. Materials and Methods: Anonymous surveys were distributed to 40 senior students and 37 new interns at UST, in Sana'a, Yemen. They were asked to indicate their self-confidence level using a Likert scoring system ranging from 1 and 5. Mann-Whitney U test and chi-squared test were used to determine statistical significance between the studied groups. Results: 37.5% of students and 35.1% of interns rated endodontic practice as difficult. Only 55% of students found that the number of treated cases were satisfactory, similar to that reported by interns (56.8%). There were no statistically significant differences between both groups regarding self-confidence levels for most endodontic procedures (p<0.05). Placing of a rubber dam, followed by managing inter-appointment flare-ups were procedures in which both groups reported the lowest confidence. On the other hand, both groups felt the lowest confidence in the treatment of maxillary followed by mandibular molars. Statistically significant differences were reported between the two groups for performing root canal treatments (RCT) (p< 0.05). Self-confidence levels on the management of most different indications showed no statistically significant differences between both groups (p>0.05) with exception to the management of irreversible pulpitis, necrotic pulp, asymptomatic apical periodontitis, chronic abscess, and traumatic cases, in which significant differences were noticed (p<0.05). Immature apices, root resorption, endodontic-periodontal (EP) lesions, trauma, symptomatic apical periodontitis and acute abscess were ranked as the cases in which both groups reported the lowest confidence. Canal blockage and ledge formation were the main mishaps encountered during practice among students and interns. Conclusion: Students and interns displayed neutral confidence in performing endodontic treatments.

Objetivo: El presente estudio tuvo como objetivo recopilar información de estudiantes de último año y nuevos pasantes inscritos en la Facultad de Odontología, Universidad de Ciencia y Tecnología (UST), con respecto a sus niveles de confianza en la realización de tratamientos de endodoncia. Materiales y métodos: se distribuyeron encuestas anónimas a 40 estudiantes de último año y 37 nuevos pasantes en UST, en Sana'a, Yemen. Se les pidió que indicaran su nivel de confianza en sí mismos utilizando un sistema de puntuación Likert que oscilaba entre 1 y 5. Se utilizaron la prueba U de Mann-Whitney y la prueba de ji al cuadrado para determinar la significación estadística entre los grupos estudiados. Resultados: el 37.5% de los estudiantes y el 35.1% de los pasantes calificaron la práctica de endodoncia como difícil. Solo el 55% de los estudiantes encontró que el número de casos tratados fue satisfactorio, similar al reportado por los pasantes (56.8%). No hubo diferencias estadísticamente significativas entre ambos grupos con respecto a los niveles de autoconfianza para la mayoría de los procedimientos de endodoncia (p<0.05). La colocación de una presa de goma, seguida de la gestión de brotes entre citas, fueron procedimientos en los que ambos grupos informaron la menor confianza. Por otro lado, ambos grupos sintieron la menor confianza en el tratamiento del maxilar seguido de los molares mandibulares. Se informaron diferencias estadísticamente significativas entre los dos grupos para realizar tratamientos de conducto radicular (ECA) (p<0.05). Los niveles de autoconfianza en el manejo de la mayoría de las indicaciones diferentes no mostraron diferencias estadísticamente significativas entre ambos grupos (p>0.05) con excepción del manejo de pulpitis irreversible, pulpa necrótica, periodontitis apical asintomática, absceso crónico y casos traumáticos, en los cuales se notaron diferencias (p<0.05). Los ápices inmaduros, la reabsorción radicular, las lesiones endodóncicas-periodontales (EP), los traumatismos, la periodontitis apical sintomática y el absceso agudo se clasificaron como los casos en que ambos grupos informaron la menor confianza. El bloqueo del canal y la formación de repisas fueron los principales percances encontrados durante la práctica entre estudiantes y pasantes. Conclusión: los estudiantes y los pasantes mostraron una confianza neutral en la realización de tratamientos de endodoncia.

Risk factors associated with the recent cholera outbreak in Yemen: a case-control study / 한국역학회지

OBJECTIVES: The cholera outbreak in Yemen has become the largest in the recent history of cholera records, having reached more than 1.4 million cases since it started in late 2016. This study aimed to identify risk factors for cholera in this outbreak. METHODS: A case-control study was conducted in Aden in 2018 to investigate risk factors for cholera in this still-ongoing outbreak. In total, 59 cholera cases and 118 community controls were studied. RESULTS: The following risk factors were associated with being a cholera case in the bivariate analysis: a history of travelling and having had visitors from outside Aden Province; eating outside the house; not washing fruit, vegetables, and khat (a local herbal stimulant) before consumption; using common-source water; and not using chlorine or soap in the household. In the multivariate analysis, not washing khat and the use of common-source water remained significant risk factors for being a cholera case. CONCLUSIONS: Behavioural factors and unsafe water appear to be the major risk factors in the recent cholera outbreak in Yemen. In order to reduce the risk of cholera, hygiene practices for washing khat and vegetables and the use and accessibility of safe drinking water should be promoted at the community level.

Cholera: an overview with reference to the Yemen epidemic / 医学前沿

Cholera is a secretory diarrhoeal disease caused by infection with Vibrio cholerae, primarily the V. cholerae O1 El Tor biotype. There are approximately 2.9 million cases in 69 endemic countries annually, resulting in 95 000 deaths. Cholera is associated with poor infrastructure and lack of access to sanitation and clean drinking water. The current cholera epidemic in Yemen, linked to spread of V. cholerae O1 (Ogawa serotype), is associated with the ongoing war. This has devastated infrastructure and health services. The World Health Organization had estimated that 172 286 suspected cases arose between 27th April and 19th June 2017, including 1170 deaths. While there are three oral cholera vaccines prequalified by the World Health Organization, there are issues surrounding vaccination campaigns in conflict situations, exacerbated by external factors such as a global vaccine shortage. Major movements of people complicates surveillance and administration of double doses of vaccines. Cholera therapy mainly depends on rehydration, with use of antibiotics in more severe infections. Concerns have arisen about the rise of antibiotic resistance in cholera, due to mobile genetic elements. In this review, we give an overview of cholera epidemiology, virulence, antibiotic resistance, therapy and vaccines, in the light of the ongoing epidemic in Yemen.

Risk factors associated with the recent cholera outbreak in Yemen: a case-control study / 한국역학회지

OBJECTIVES: The cholera outbreak in Yemen has become the largest in the recent history of cholera records, having reached more than 1.4 million cases since it started in late 2016. This study aimed to identify risk factors for cholera in this outbreak.METHODS: A case-control study was conducted in Aden in 2018 to investigate risk factors for cholera in this still-ongoing outbreak. In total, 59 cholera cases and 118 community controls were studied.RESULTS: The following risk factors were associated with being a cholera case in the bivariate analysis: a history of travelling and having had visitors from outside Aden Province; eating outside the house; not washing fruit, vegetables, and khat (a local herbal stimulant) before consumption; using common-source water; and not using chlorine or soap in the household. In the multivariate analysis, not washing khat and the use of common-source water remained significant risk factors for being a cholera case.CONCLUSIONS: Behavioural factors and unsafe water appear to be the major risk factors in the recent cholera outbreak in Yemen. In order to reduce the risk of cholera, hygiene practices for washing khat and vegetables and the use and accessibility of safe drinking water should be promoted at the community level.

Clinical Manifestations of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome from a Single Center

PURPOSE: Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is a leading cause of periodic fever in children. This study describes the clinical characteristics of PFAPA syndrome in patients from a single center.METHODS: Thirteen children diagnosed with PFAPA syndrome at Seoul National University Children's Hospital were included in this study. Retrospective medical chart reviews were performed.RESULTS: Among the 13 patients, 8 (61.5%) were male. The median follow-up duration was 3.3 years (range, 10 months–8.3 years). The median age of periodic fever onset was 3 years (range, 1–6 years). All patients had at least 5 episodes of periodic fever and pharyngitis, managed with oral antibiotics, before diagnosis. The median occurrence of fever was every 3.9 weeks and lasted for 4.2 days. All patients had pharyngitis and 12 (92.3%) had cervical lymphadenitis. Blood tests were performed for 12 patients, and no patients had neutropenia. Both the C-reactive protein and erythrocyte sedimentation rate were elevated at medians of 4.5 mg/dL (range, 0.4–13.2 mg/dL) and 29 mm/hr (range, 16–49 mm/hr), respectively. Throat swab cultures and rapid streptococcal antigen tests were negative. Nine (69.2%) patients received oral prednisolone at a median dose of 0.8 mg/kg, and in 6 (66.7%) patients, fever resolved within a few hours. Three (23.1%) patients received tonsillectomy and adenoidectomy.CONCLUSIONS: PFAPA syndrome should be considered when a child presents with periodic fever along with aphthous stomatitis, pharyngitis, or cervical lymphadenitis. Glucocorticoid administration is effective for fever resolution and can reduce unnecessary use of antibiotics.

Clinical efficacy of nanosilver and chlorhexidine in the treatment of plaque-induced gingivitis: a randomized controlled clinical trial

Aim: the present study aimed to assess the clinical efficacy of nanosilver (NS) mouthwash and compared with chlorhexidine (CHX) mouthwash for the treatment of plaque-induced gingivitis. materials and methods: sixty-two (28 males and 34 females) plaque-induced gingivitis patients were allocated into two groups and asked to rinse with 10ml of NS or CHX, immediately after brushing, for 1 min, in the morning and evening. the plaque, gingival, and papilla bleeding indices were taken at baseline, two weeks, and finally at four weeks for each patient. the statistical analysis between and within groups were performed using Mann-Whitney U-test and Wilcoxon signed rank test respectively. result: Intergroup comparison by Mann-Whitney U-test showed no statistically significant differences in the investigated groups at the baseline for all studied parameters. at 2 and 4 weeks follow up, the CHX group showed statistically significant lower plaque scores than the NS group (p<0.05). however, there is no statistically significant difference between NS and CHX groups for gingival and papilla bleeding scores (p>0.05). both groups showed statistically significant reductions in plaque, gingival and papilla bleeding scores after 2 weeks and 4 weeks of product use when compared to baseline (p<0.001). conclusion: both mouthwashes decreased plaque, gingival and papilla bleeding scores, however the reduction in plaque scores was higher for the CHX group compared to the NS group.

Seropositivity of Hepatitis C Virus among Persons affected Leprosy in Korea / 나학회지

BACKGROUND: Leprosy is a contagious chronic granulomatous disease and is a disease that is associated with defects in cellular immunity. A high prevalence of hepatitis C virus infection in leprosy patients has been reported in several African countries, Yemen, Brazil and Japan. In Korea, it's seropositivity was reported as 8.33%(2001), 39.3%(2002), 35.1%(2009) and 16.0%(2009) on Korean Leprosy Bulletin. OBJECTIVE: In the meantime, the studies were limited to the subjects in a specific region, and the number of subjects was not enough, so it was not enough to evaluate the hepatitis C virus seropositivity of persons affected by leprosy in Korea. So this study was conducted to evaluate the it's seropositivity in settlement villages nationwide. METHOD: This study was conducted that the mobile team visited the resettlement villages nationwide from 2009 to 2017 and conducted on persons affected by leprosy and residents residing in resettlement village. Obtained serums were assayed by the ADVIA Centaur HVC(IgG antibodies to Hepatitis C Virus) reagent using a Siemens ADVIA Centaur CP instrument. The results of persons affected by leprosy and residents were compared, and the difference of seropositivity among the groups(male and female, multibacillary and paucibacillary, locations of resettlement villages) was evaluated. RESULT: The results of hepatitis C virus antibody positivity of 1669 persons affected by leprosy subjects and 185 residents of resettlement villages were 28.46% in persons affected by leprosy and 6.49% in residents(Pearson's Chi-Square test, P = 0.00). In persons affected by leprosy, that were 31.99%(male) and 26.84%(female)(Pearson's Chi-Square test, P = 0.06) and were 29.97%(multibacillary) and 25.36%(paucibacillary)(Pearson's Chi-Square test, P = 0.05). That of Seoul(48.28%), Busan(43.78%) and Chungbuk Province(35.94%) were highly positive and that of Gangwon Province(20.34%) was lowly positive(Fisher's Exact test P = 0.002). CONCLUSION: In this study, we found that hepatitis C virus antibody positivity rate was high in persons affected by leprosy in Korea. In order to explain the high positive rate, further studies will be needed. Also, through various approaches including assessment of HCV RNA to the subjects who were judged to be positive for antibody test in the future, a comprehensive evaluation of hepatitis C and its countermeasures are needed.

Management of temporomandibular joint ankylosis in yemeni children by metatarsal bone grafts

Aim: This study aimed to evaluate temporomandibular joint reconstruction in Yemeni children with metatarsal bone graft after release of ankylosis. Methodology: Ten patients ≤12 years of age, comprising eight unilateral and two bilaterally TMJ ankylosis, were selected for this study. These patients underwent reconstruction with 10 non-vascularized metatarsal grafts. The reconstructed joints were then followed for an average of 1 year. Measures of opening, symmetry, and clinical symptoms relating to the reconstructed joints were assessed. Results: Mean pre-operative interincisal aperture was 8.2mm, and immediate post-operative aperture 23.4mm. At the end of the follow-up period, acceptable results were achieved in 8 out of 10 cases, with adequate mouth opening of 35.6mm in 8 out of 10 patients and overall interincisal aperture of 30.3mm. Re-ankylosis occurred in two bilaterally-treated patients at the end of follow-up. Subjectively, 80 percent of the patients rated their function as satisfactory and were able to occlude and masticate without any difficulty. Conclusion: Reconstruction of TMJ after release of ankylosis utilizing metatarsal bone graft shows a satisfactory interincisal aperture in 80 percent of patients.

Profesores cubanos enseñando Medicina, en un país árabe, en inglés / Cuban professors, teaching Medicine, in an Arabic country, in English

Introducción: La colaboración médica cubana no se ha limitado al campo de la atención de salud, también ha incluido la formación de recursos humanos autóctonos, incluyendo la creación de Facultades de Medicina en el exterior. La Facultad de Medicina de la República Democrática de Yemen es un destacado ejemplo de esta actividad. Objetivo: describir algunas características y singularidades de este relevante hecho de la colaboración médica cubana. Material y Métodos: Se realizó un trabajo histórico descriptivo, a partir de materiales periodísticos, fotografías, el diario personal y otros documentos del archivo del autor. Desarrollo: La Facultad de Medicina de Adén fue creada en 1975 con la participación de profesores cubanos en calidad de colaboradores. Durante su segundo curso, esta Facultad recibió la visita del Comandante en Jefe, Fidel Castro Ruz, durante su estancia en la República Democrática de Yemen, en marzo de 1977. La prensa yemenita brindó amplia cobertura a la visita. Fidel tuvo palabras de estímulo y admiración por la realización de esta tarea de colaboración. Conclusiones: La constitución de la Facultad de Medicina en la República Democrática de Yemen, en 1975, constituyó un hito histórico relevante en el desarrollo de la colaboración médica cubana. La visita de Fidel Castro a la Facultad de Medicina en Adén en marzo de 1977 fue un estímulo de especial significación para los colaboradores cubanos(AU)

Introducción: Cuban medical collaboration has not been limited to the field of health care, it has also included the training of own human resources, including the creation of Medical Faculties in other countries. The Faculty of Medicine of the Democratic Republic of Yemen is a leading example of this activity. Objective: To describe some characteristics and singularities of this relevant historical event of the Cuban medical collaboration. Material and Methods: A descriptive historical research was done, based on journalistic materials, photographs, personal diary and other documents of the author's archives. Development: The Faculty of Medicine of Aden was created in 1975 with the participation of Cuban professors as collaborators. During its second course, this Faculty received the visit of Commander-in-Chief Fidel Castro Ruz during his stay in the Democratic Republic of Yemen in March of 1977. The Yemeni press provided a wide coverage to the visit. Fidel had words of encouragement and admiration for the accomplishment of this collaboration. Conclusions: The creation of the Faculty of Medicine in the Democratic Republic of Yemen in 1975 was an important historical milestone in the development of Cuban medical collaboration. Fidel Castro's visit to the Faculty of Medicine in Aden in March 1977 was a stimulus of special significance for Cuban collaborators.(AU)

Tongue lesions and anomalies in a sample of Yemeni dental patients: a cross-sectional study

Background: Tongue examination helps considerably in diagnosing the underlying health state of the patient, especially in the cases of chronic diseases. The aim of this study is to determine the prevalence and association of tongue lesions with risk factors among Yemeni dental patients. Materials and methods: An oral medicine specialist examined all 713 patients attending the dental polyclinics at the University of Sciences and Technology (Sana’a, Yemen). The examination sheet was designed to include information related to patient characteristics, medical history, dental history, habits, and tongue lesions. Results: The prevalence of tongue lesions among the examined participants was 76.5 percent. The prevalence rate was 83.4 percent for males and 69.2 percent for females. Fissured tongue was the most common condition. Logistic regression analysis indicated that older age (p<0.001), gender (p=0.007), khat chewing (p<0.001), and smoking (p=0.001) were associated with fissured tongue; gender (p<0.001), khat chewing (p<0.001), and smoking (p<0.001) were associated with hairy tongue; and older age (p<0.001), khat chewing (p=0.001), and smoking (p=.021) were associated with coated tongue. Conclusion: The prevalence of tongue lesions among this sample of Yemeni population was 76.5 percent; fissured tongue and hairy tongue were the most prevalent lesions. Khat chewing, smoking, and older age were the associated risk factors for many of studied lesions and anomalies.

Cross-sectional assessment of the periapical status as related to quality of root canal fillings and coronal restorations in a Yemeni population

Aim: the present study aimed to examine the influence of the quality of root canal fillings and coronal restorations on the prevalence of periapical lesions. Materials and Methods: Two hundred digital panoramic radiographs were obtained from the archive of Al‑HamziDental Center in Sana’a, Yemen. The final sample consisted of 120 radiographs, and 675 root filled teeth.The quality of root canal fillings was scored according to criteria of length, homogeneity and taper. Coronal status (type of restoration, signs of marginal leakage or decay) was also evaluated. The periapical status was categorized on the basis of presence or absence of radiographical signs of apical periodontitis. Chi-square test was used to determine statistical significance between different parameters. Results: We found that 93.6 percent of root filled teeth were associated with apical periodontitis. Only 9.2 percent of root filled teeth were found to have an acceptable standard of root canal fillings, of which 32.3 percent was also associated to signs of periapical disease. In roots with an unacceptable root canal filling, 95.4 percent had periapical disease. Teeth with good (14.4 percent) and poor (32.9 percent) intra-coronal restorations had apical periodontitis in 93.8 percent and 97.7 percent of cases, respectively. Crown restorations were present in 52.7 percent of root filled teeth, of which 91.0 percent were associated with periapical lesions. Conclusion: The poor technical quality of root canal fillings and coronal restorations is consistent with a high prevalence of apical periodontitis.

Consumer Perception Of The Health Care Services In Yemen And Its Impact On Self-Medication Practice

@#Community pharmacists are expected to have the necessary knowledge to give advice on safe and appropriate drug use during self-medication. However, the profession of pharmacist in Yemen has become less trustworthy and less reliable. In addition, quality of medication has been raising a lot of questions among consumers and fake medications have been entering the country without quality control checks. The aim of this study was to determine the consumer perception of health care services provided and its impact on self-medication practice in Sana’a city, Yemen. A self-administered questionnaire containing open-ended and closed-ended questions was developed and distributed among 400 consumers attending 10 community pharmacies in Sana’a City. All data obtained from the questionnaires were coded, entered, and analysed using Chi-square test and multiple logistic regressions. Prevalence of self-medication was found to be 90.7 %. The majority of respondents stated that they do not trust the health care services provided by physician (68.8%), community drug dispensers (78.2%), Ministry of Health (70.5%) or the quality of medicine dispensed by community pharmacies (59.7%). The trust of health care services provided by physicians and community drug dispensers were found to be significant predictors of self-medication practice. Those who did not trust health care services provided by physicians were more likely to use self-medication compared to those who did not (OR= 21.212, CI 95% 2.678-168.001, p= 0.004). Those who did not trust health care services provided by community drug dispensers were more likely to use self-medication compared to those who did not (OR= 2.746, CI 95% 1.048-7.195, p= 0.04). Consumers in Sana’a City have a negative overall perception of the services provided by community drug dispensers, physician and Ministry of Health and the quality of medication. An urgent intervention from health care authorities to adopt and to implement a new national drug policy with necessary laws and regulations is needed

Radiographic evaluation of root canal fillings in a selected Yemeni population: a retrospective study / Evaluación radiográfica de tratamientos de endodoncia realizados en una población Yemení: estudio retrospectivo

Abstract: aim: to assess the root canal filling quality performed by general dental practitioners in Yemen through radiographic evaluation. Materials and Methods: Four hundred fifty-five digital panoramic radiographs were selected from the archive of the Dental Health Center in Sana'a, Yemen. The final sample consisted of 221 patients, 685 teeth, and 977 root canals. The criteria for overall radiographic adequacy of root canal fillings were defined as the presence of adequate length, density and taper, and absence of iatrogenic errors (ledges, transportations and perforations). Chi-square test was used to determine statistical significance between different parameters. Results: This study considered only radiographic criteria for evaluation of the root canal fillings. The percentage of root canal fillings with adequate length, density and taper was 30.8 percent, 29.6 percent and 20.7 percent, respectively. Considering the incidence of iatrogenic errors, perforations were present in 12 root canals (1.2 percent), while the presence of transportations was observed in 20 root canals (2.0 percent). However, ledges were no detected in any root canals. Conclusion: The root canal filling quality performed by general dental practitioners in Yemen is poor.

Resumen: objetivo: evaluar a través de la evaluación radiográfica la calidad de los tratamientos de endodoncia realizados por odontólogos generales en Yemen. Materiales y Métodos: Cuatrocientos cincuenta y cinco radiografías panorámicas digitales fueron seleccionados desde el archivo del Centro de Salud Dental en Sana'a, Yemen. La muestra final fue de 221 pacientes, 685 dientes y 977 endodoncias. Los criterios de adecuación radiográfica general de los tratamientos de endodoncia se definieron como la presencia de longitud adecuada, la densidad y la forma cónica y la ausencia de errores iatrogénicos (proyecciones, transportaciones y perforaciones). Se utilizó la prueba de chi-cuadrado para determinar la significación estadística entre los diferentes parámetros. Resultados: En este estudio se consideró sólo criterios radiológicos para la evaluación de las obturaciones del conducto radicular. El porcentaje de obturaciones del conducto radicular con la longitud adecuada, la densidad y la forma cónica fue del 30,8 por ciento, 29,6 por ciento y 20,7 por ciento, respectivamente. Teniendo en cuenta la incidencia de errores iatrogénicos, las perforaciones estaban presentes en 12 tratamientos (1,2 por ciento), mientras que se observó la presencia de transportaciones en 20 tratamientos (2,0 por ciento). Sin embargo, las proyecciones no fueron detectadas en ningún tratamiento. Conclusión: La calidad de los tratamientos de endodoncia realizados por dentistas generales de Yemen es pobre.

Antifungal Activity of Lactic Acid Bacteria Strains Isolated from Natural Honey against Pathogenic Candida Species

The role of lactic acid bacteria (LAB) in honey as antifungal activity has received little attention and their mechanism of inhibitory of fungi is not fully understood. In this study, LAB were isolated from honey samples from Malaysia, Libya, Saudi Arabia, and Yemen. Twenty-five isolates were confirmed LAB by catalase test and Gram staining, and were screened for antifungal activity. Four LAB showed inhibitory activity against Candida spp. using the dual agar overlay method. And they were identified as Lactobacillus plantarum HS isolated from Al-Seder honey, Lactobacillus curvatus HH isolated from Al-Hanon honey, Pediococcus acidilactici HC isolated from Tualang honey and Pediococcus pentosaceus HM isolated from Al-Maray honey by the 16S rDNA sequence. The growth of Candida glabrata ATCC 2001 was strongly inhibited (>15.0 mm) and (10~15 mm) by the isolates of L. curvatus HH and P. pentosaceus HM, respectively. The antifungal activity of the crude supernatant (cell free supernatant, CFS) was evaluated using well diffusion method. The CFS showed high antifungal activity against Candida spp. especially The CFS of L. curvatus HH was significantly (p < 0.05) inhibited growth of C. glabrata ATCC 2001, C. parapsilosis ATCC 2201, and C. tropicalis ATCC 750 with inhibitory zone 22.0, 15.6, and 14.7 mm, respectively. While CFS of P. pentosaceus HM was significantly (p < 0.05) effective against C. krusei, C. glabrata, and C. albicans with inhibition zone 17.2, 16.0, and 13.3 mm, respectively. The results indicated that LAB isolated from honey produced compounds which can be used to inhibit the growth of the pathogenic Candida species.